In West Africa, Single-Dose Antibiotic Treats Vaginal Discharge as Effectively as Multiple-Dose Treatment
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Treatment of Bacterial Vaginosis: A Multicenter, Double-Blind, Double-Dummy, Randomised Phase III Study Comparing Secnidazole and Metronidazole
OBJECTIVE Multiple-dose metronidazole oral therapy is currently the reference treatment for bacterial vaginosis (BV). This double-blind, double-dummy, noninferiority study compared the efficacy of secnidazole, another nitroimidazole with pharmacokinetics allowing a single dose regimen, to this standard treatment. METHODS A total of 577 patients were randomized to receive metronidazole (500 mg...
متن کاملLow prevalence of cervical infections in women with vaginal discharge in west Africa: implications for syndromic management.
OBJECTIVES To measure prevalence and risk factors for cervical infections among a large sample of women consulting for vaginal discharge in west Africa and to evaluate its syndromic management through a two visit algorithm. METHODS In 11 health centres in Bénin, Burkina Faso, Ghana, Guinée, and Mali 726 women who presented with a vaginal discharge without abdominal pain and who denied being a...
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Background & Aims: Ectopic pregnancy currently is the leading cause of pregnancy-related death during the first trimester. The methotrexate (MTX) was accepted as medical treatment and reduced surgery in unruptured ectopic pregnancy. Despite numerous studies, the best protocol for MTX treatment remains controversial. The present study compares single and two dose MTX administrations protocol in ...
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P rompt treatment of sexually transmitted infections (STIs) with effective antibiotic regimens, preferably contained in a single, supervised dose, is a cornerstone of STI control. The World Health Organization (WHO) revised its treatment guidelines in 2001. A variety of regimens is proposed, from which national control programmes are encouraged to choose, depending on the susceptibility of loca...
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Complex pharmacokinetic (PK) properties including nonlinear elimination were encountered by some monoclonal antibodies (mAbs), and classic compartment models sometimes failed to appropriately describe those properties. In this work, a new model was built on a comprehensive analysis of the complex elimination of mAbs. This new model was firstly utilized to fit with the single-dose plasma concent...
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تاریخ انتشار 2006